Company Filing History:
Years Active: 2019-2025
Title: Paul Hartley: Innovator in Genomic Technologies
Introduction
Paul Hartley is a prominent inventor based in San Jose, CA, known for his significant contributions to genomic technologies. With a total of 7 patents, he has made remarkable strides in the field of genome assembly and haplotype phasing.
Latest Patents
Hartley's latest patents include groundbreaking methods for the generation of phased read-sets for genome assembly and haplotype phasing. These innovations involve techniques that facilitate accurate phasing of genomic sequence data through the segmentation and rearrangement of nucleic acid molecules. His work preserves the phase or physical linkage information of individual molecules by binding them independently of their phosphodiester backbones, cleaving, ligating, and sequencing them using long-read sequencing technology. Another notable patent focuses on tagging nucleic acids for sequence assembly. This patent presents various approaches for generating long-distance contiguity information to aid in contig assembly and phase determination. Nucleic acids are assembled into complexes using binding moieties, ensuring that fragments remain bound even after the backbones are cleaved. The exposed ends are tagged and ligated, allowing for sequencing that helps assemble contigs into common scaffolds or assign phase information.
Career Highlights
Throughout his career, Paul Hartley has been instrumental in advancing genomic research. His innovative approaches have not only enhanced the accuracy of genomic sequencing but have also paved the way for new methodologies in the field.
Collaborations
Hartley collaborates with notable colleagues, including Nicholas H Putnam and Marco Blanchette, contributing to a dynamic research environment that fosters innovation and discovery.
Conclusion
Paul Hartley's work exemplifies the intersection of innovation and technology in the realm of genomics. His patents and collaborative efforts continue to influence the future of genetic research and applications.
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