Company Filing History:
6 out of 197 
4 out of 48 
2 out of 22 
Years Active: 1995-2016
Title: The Innovative Contributions of Paul Brust
Introduction
Paul Brust is a notable inventor based in San Diego, California, with a remarkable portfolio of 14 patents. His work primarily focuses on advancements in taste perception and electrophysiological assays, contributing significantly to the fields of biochemistry and sensory science.
Latest Patents
One of Brust's latest patents is titled "Cell-based fluorescent assays for identifying alpha and delta ENaC modulators." This invention relates to improved electrophysiological assays that measure sodium conductance activity of a delta or alpha human epithelial sodium channel (ENaC) expressed in a test cell. The method involves contacting the test cells with sodium ions, typically ranging from 15 mM to 140 mM, for a sufficient time before screening against potential enhancers. This sodium pretreatment has been found to enhance assay sensitivity, particularly in assays using membrane potential or ion-sensitive dyes. The compounds discovered have potential applications in modulating salty taste perception and treating disorders related to aberrant hENaC function.
Another significant patent involves "Compounds that inhibit (block) bitter taste in composition and methods of making same." This invention uncovers specific human taste receptors in the T2R family that respond to certain bitter compounds, such as those found in coffee. Brust's research led to the identification of compounds that act as bitter taste blockers, which can be utilized in coffee and coffee-flavored products. Additionally, the invention includes a compound that antagonizes various human T2Rs, which can be used in assays and as a bitter taste blocker in consumable compositions.
Career Highlights
Throughout his career, Paul Brust has worked with prominent companies such as Senomyx, Inc. and Sibia Neurosciences, Inc. His innovative contributions have significantly impacted the understanding of taste perception and the development of new flavor-modulating compounds.
Collaborations
Brust has collaborated with notable individuals in his field, including Michael Miller Harpold and Guy Servant. These collaborations have further enriched his research and development efforts.
Conclusion
Paul Brust's inventive work and patents have made substantial contributions to the fields of taste perception and electrophysiological assays. His innovative approaches continue to influence research and applications in sensory science.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.