The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 04, 2006
Filed:
Feb. 03, 2004
Guy Servant, San Diego, CA (US);
Mark Ozeck, San Diego, CA (US);
Paul Brust, San Diego, CA (US);
Hong Xu, San Diego, CA (US);
Guy Servant, San Diego, CA (US);
Mark Ozeck, San Diego, CA (US);
Paul Brust, San Diego, CA (US);
Hong Xu, San Diego, CA (US);
Senomyx, Inc., LaJolla, CA (US);
Abstract
The invention resides in part in the discovery that G proteins other than Gαcouples to T1R and T2R taste receptors, particularly Gproteins such as G. Related to this discovery, the invention provides cell-based assay methods for identifying compounds that modulate the activity of specific T1R or T2R taste receptors or which modulate the effect of other T1R or T2R modulators on T1R or T2R activity. These assay methods preferably detect the effect of a putative T1R or T2R modulator compound on MAPK activation, cAMP accumulation, or adenylyl cyclase activity or another signaling pathway regulated by Gproteins. The level of MAPK activation, cAMP accumulation or adenylyl cyclase is preferably determined by immunoassay methods that use ligands (monoclonal or polyclonal antibodies) that specifically bind an activated (phosphorylated) MAPK, cAMP, or adenylyl cyclase.