Pasha M Khan

Title: Innovations by Pasha M Khan

Introduction

Pasha M Khan is an accomplished inventor based in Tampa, FL (US). He has made significant contributions to the field of chemistry, particularly in the synthesis of optically pure heterocyclic compounds. With a total of 2 patents, his work has opened new avenues for antiviral and anticancer applications.

Latest Patents

His latest patents include the "Antiviral activity of cyclopentene nitro-ester and derivatives." This patent discloses a method for synthesizing new optically pure heterocyclic compounds using Pd(0) catalyzed intramolecular cyclizations. The analogs of cyclopentanes, such as isoxazoline-2-oxide and furan, exhibit anti-HIV and anticancer properties, thereby expanding the potential applications of these compounds. The synthesis begins with a meso-diol, allowing for the preparation of optically pure compounds without the use of chiral ligands at any stage. The stereochemical outcome of the product, achieving greater than 99% enantiomeric excess (ee), is influenced by desymmetrization catalyzed by lipase and the stereoselective nature of the palladium-catalyzed transformations.

Career Highlights

Pasha M Khan is affiliated with the University of South Florida, where he continues to advance his research and innovation in the field of chemistry. His work is characterized by a commitment to developing new methodologies that can have a significant impact on health and medicine.

Collaborations

Some of his notable coworkers include Kirpal Singh Bisht and Alberto Van Olphen, who contribute to the collaborative environment that fosters innovation and research excellence.

Conclusion

Pasha M Khan's contributions to the field of chemistry through his patents and research at the University of South Florida highlight his role as a leading inventor. His work not only advances scientific knowledge but also has the potential to improve health outcomes through innovative applications.