University of South Florida

Pasha M Khan

Kirpal Singh Bisht

Alberto Van Olphen

Ruizhi Wu

Cynthia Bucher

Disclosed is a method of synthesizing new optically pure heterocyclic compounds using Pd(0) catalyzed intramolecular cyclizations. Analogs of cyclopentanes, like isoxazoline-2-oxide and furan, with similar framework to the cyclopentanes act as anti-HIV and anticancer agents which opens a whole new field for application of these compounds. Starting from a meso-diol, optically pure compounds were prepared without utilizing chiral ligands at any stage of the synthesis. The stereochemical outcome of the product (&#x3e;99% ee) was influenced by desymmetrization catalyzed bylipase and the stereo selective nature of the palladium catalyzed transformations.

Antiviral activity of cyclopentene nitro-ester and derivatives

Disclosed is a method of synthesizing new optically pure heterocyclic compounds using Pd(0) catalyzed intramolecular cyclizations. Analogs of cyclopentanes, like isoxazoline-2-oxide and furan, with similar framework to the cyclopentanes act as anti-HIV and anticancer agents which opens a whole new field for application of these compounds. Starting from a meso-diol, optically pure compounds were prepared without utilizing chiral ligands at any stage of the synthesis. The stereochemical outcome of the product (&#x3e;99% ee) was influenced by desymmetrization catalyzed bylipase and the stereoselective nature of the palladium catalyzed transformations.

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Tampa, FL, United States of America

Pasha M Khan