The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 27, 2012
Filed:
Jun. 09, 2010
Kirpal S. Bisht, Tampa, FL (US);
Alberto Van Olphen, Tampa, FL (US);
Pasha M. Khan, Tampa, FL (US);
Cynthia Bucher, Temple Terrace, FL (US);
Kirpal S. Bisht, Tampa, FL (US);
Alberto Van Olphen, Tampa, FL (US);
Pasha M. Khan, Tampa, FL (US);
Cynthia Bucher, Temple Terrace, FL (US);
University of South Florida, Tampa, FL (US);
Abstract
Disclosed is a method of synthesizing new optically pure heterocyclic compounds using Pd(0) catalyzed intramolecular cyclizations. Analogs of cyclopentanes, like isoxazoline-2-oxide and furan, with similar framework to the cyclopentanes act as anti-HIV and anticancer agents which opens a whole new field for application of these compounds. Starting from a meso-diol, optically pure compounds were prepared without utilizing chiral ligands at any stage of the synthesis. The stereochemical outcome of the product (>99% ee) was influenced by desymmetrization catalyzed bylipase and the stereo selective nature of the palladium catalyzed transformations.