Nobuhisa Shimba

Title: **Nobuhisa Shimba: Innovator in Transglutaminase Technology**

Introduction

Nobuhisa Shimba is a distinguished inventor based in Kawasaki, Japan. He has made significant contributions to the field of biochemistry, particularly through his work with transglutaminase, an enzyme with various applications in both food and pharmaceutical industries. With a total of five patents to his name, Shimba is recognized for his innovative approaches to enzyme modification.

Latest Patents

Among Shimba's latest patents is a groundbreaking invention titled "Polynucleotide encoding a mutant transglutaminase." This invention relates to a method for designing and preparing mutant transglutaminases based on the three-dimensional structure derived from microbial transglutaminase (MTG). The innovation seeks to enhance the enzyme's substrate reactivity through strategic modifications at the substrate-binding site, informed by X-ray crystal structure analysis.

Another notable patent is focused on a "Protein having antithrombotic activity and method for producing the same." This invention outlines a method for producing a protein with antithrombotic properties by modifying amino acid residues in a protein with a related structure to enhance its effectiveness, significantly contributing to advancements in therapeutic proteins.

Career Highlights

Nobuhisa Shimba currently works at Ajinomoto Co., Ltd., a prominent global company recognized for its contributions to food and biotechnology. His career at Ajinomoto has allowed him to pursue innovative research, ultimately leading to various patents that enhance the functionality of enzymes and proteins.

Collaborations

Throughout his career, Nobuhisa has collaborated with esteemed colleagues, including Kohki Ishikawa and Eiichiro Suzuki. Together, they have pushed the boundaries of research in transglutaminase technology and its applications in various industries.

Conclusion

Nobuhisa Shimba's contributions to biochemistry and enzyme technology have positioned him as an influential figure in the field. His latest patents demonstrate a commitment to innovation and improvement in enzyme functionality, paving the way for new applications in both food science and medicine. As he continues to develop pioneering technologies, Shimba remains a notable inventor worth following in the world of biotechnology.