The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 01, 2006
Filed:
Jan. 02, 2004
Naoyuki Fukuchi, Kawasaki, JP;
Morikazu Kito, Kawasaki, JP;
Takashi Kayahara, Kawasaki, JP;
Fumie Futaki, Kawasaki, JP;
Kohki Ishikawa, Kawasaki, JP;
Eiichiro Suzuki, Kawasaki, JP;
Keiko Gondoh, Kawasaki, JP;
Nobuhisa Shimba, Kawasaki, JP;
Naoyuki Yamada, Kawasaki, JP;
Naoyuki Fukuchi, Kawasaki, JP;
Morikazu Kito, Kawasaki, JP;
Takashi Kayahara, Kawasaki, JP;
Fumie Futaki, Kawasaki, JP;
Kohki Ishikawa, Kawasaki, JP;
Eiichiro Suzuki, Kawasaki, JP;
Keiko Gondoh, Kawasaki, JP;
Nobuhisa Shimba, Kawasaki, JP;
Naoyuki Yamada, Kawasaki, JP;
Ajinomoto Co., Inc., Tokyo, JP;
Abstract
A method for producing a protein having an antithrombotic activity, which comprises replacing, in a protein that has an amino acid sequence having a homology of not less than 30% to the amino acid sequence of SEQ ID NO: 1 and forms a higher order structure composed of a first β strand (β1), a first a helix (α1), a second α helix (α2), a second β strand (β2), a loop, a third β strand (β3), a fourth β strand (β4) and a fifth β strand (β5) in this order from the amino terminus, at least one amino acid residue in a region from α2 to β2 and/or a region from β3 to β4 so that electric charge of the amino acid residue is changed towards positive direction.