Company Filing History:
2 out of 1,869 
1 out of 6 
1 out of 989 
Years Active: 2004-2021
Title: Innovations of Nicolas Paul Sluis-Cremer
Introduction
Nicolas Paul Sluis-Cremer is a notable inventor based in Pittsburgh, PA (US). He has made significant contributions to the field of pharmaceuticals, particularly in the development of compounds aimed at combating antibiotic resistance and viral infections. With a total of 3 patents, his work has the potential to impact public health positively.
Latest Patents
One of his latest patents focuses on the reversal of fosfomycin resistance. This invention discloses compounds, pharmaceutical compositions, and methods for reversing fosfomycin resistance. The compounds inhibit fosfomycin-inhibiting enzymes, with some embodiments being FosA inhibitors. The pharmaceutical compositions include fosfomycin or a pharmaceutically acceptable salt thereof, combined with a compound that inhibits a fosfomycin-inhibiting enzyme. A method of inhibiting the growth of a fosfomycin-resistant bacterium is also described, which involves contacting the bacterium with fosfomycin and an effective amount of a disclosed compound.
Another significant patent involves 3'-azido purine nucleotide prodrugs for the treatment of viral infections. This invention is directed towards compounds, compositions, and methods for treating or preventing viral infections, particularly HIV and HBV, in human patients or other animal hosts. The compounds are 3'-azido-2',3'-dideoxy purine monophosphates, along with their pharmaceutically acceptable salts, prodrugs, and other derivatives. These compounds demonstrate potent antiviral activity against HIV-1 and HBV.
Career Highlights
Nicolas has worked with esteemed institutions such as the University of Pittsburgh and RFS Pharma LLC. His career reflects a commitment to advancing medical science through innovative research and development.
Collaborations
Throughout his career, Nicolas has collaborated with notable figures in the field, including Raymond F. Schinazi and John W. Mellors. These collaborations have likely contributed to the success and impact of his inventions.
Conclusion
Nicolas Paul Sluis-Cremer's work exemplifies the spirit of innovation in the pharmaceutical industry. His patents address critical issues such as antibiotic resistance and viral infections, showcasing his dedication to improving health outcomes. His contributions are a testament to the importance of research and collaboration in advancing medical science.