The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 20, 2021
Filed:
Jan. 11, 2018
University of Pittsburgh—of the Commonwealth System of Higher Education, Pittsburgh, PA (US);
University of Maryland, Baltimore, Baltimore, MD (US);
Nicolas Paul Sluis-Cremer, Pittsburgh, PA (US);
Adam Daniel Tomich, Pittsburgh, PA (US);
Yohei Doi, Pittsburgh, PA (US);
Eric J. Sundberg, Baltimore, MD (US);
Erik H. Klontz, Baltimore, MD (US);
Steven Fletcher, Baltimore, MD (US);
University of Pittsburgh—of the Commonwealth System of Higher Education, Pittsburgh, PA (US);
University of Maryland, Baltimore, Baltimore, MD (US);
Abstract
Compounds, pharmaceutical compositions, and methods for reversing fosfomycin resistance are disclosed. Embodiments of the disclosed compounds inhibit fosfomycin-inhibiting enzymes. Some embodiments of the compounds are FosA inhibitors. The disclosed pharmaceutical compositions include (i) fosfomycin or a pharmaceutically acceptable salt thereof and (ii) a compound, or a pharmaceutically acceptable salt thereof, which inhibits a fosfomycin-inhibiting enzyme. A method of inhibiting growth of a fosfomycin-resistant bacterium includes contacting the bacterium with (i) fosfomycin or a pharmaceutically acceptable salt thereof and (ii) an effective amount of a disclosed compound or a pharmaceutically acceptable salt thereof.