The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 26, 2014

Filed:

Dec. 09, 2009
Applicants:

Raymond F. Schinazi, Atlanta, GA (US);

John W. Mellors, Pittsburgh, PA (US);

Nicolas Paul Sluis-cremer, Pittsburgh, PA (US);

Steven J. Coats, McDonough, GA (US);

Richard Anthony Whitaker, Loganville, GA (US);

Brian David Herman, Pittsburgh, PA (US);

Jong Hyun Cho, Snellville, GA (US);

Longhu Zhou, Atlanta, GA (US);

Hongwang Zhang, Tucker, GA (US);

Inventors:

Raymond F. Schinazi, Atlanta, GA (US);

John W. Mellors, Pittsburgh, PA (US);

Nicolas Paul Sluis-Cremer, Pittsburgh, PA (US);

Steven J. Coats, McDonough, GA (US);

Richard Anthony Whitaker, Loganville, GA (US);

Brian David Herman, Pittsburgh, PA (US);

Jong Hyun Cho, Snellville, GA (US);

Longhu Zhou, Atlanta, GA (US);

Hongwang Zhang, Tucker, GA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07H 19/04 (2006.01); A61K 31/70 (2006.01); C07H 19/20 (2006.01); C07D 473/16 (2006.01); C07H 19/173 (2006.01); C07D 473/18 (2006.01); C07H 19/207 (2006.01); A61K 31/437 (2006.01);
U.S. Cl.
CPC ...
C07D 476/34 (2013.01); C07H 19/20 (2013.01); C07D 473/16 (2013.01); C07H 19/173 (2013.01); C07D 473/18 (2013.01); C07H 19/207 (2013.01); A61K 31/437 (2013.01);
Abstract

The present invention is directed to compounds, compositions and methods for treating or preventing viral infections, in particular, HIV, and HBV, in human patients or other animal hosts. The compounds are 3'-azido-2′,3′-dideoxy purine monophosphates, and pharmaceutically acceptable, salts, prodrugs, and other derivatives thereof. In particular, the compounds show potent antiviral activity against HIV-1 and HBV.


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