Nicolas Duverger

Title: Innovations of Nicolas Duverger

Introduction

Nicolas Duverger is a prominent inventor based in Paris, France. He has made significant contributions to the field of biotechnology, particularly in the regulation of genes associated with cholesterol metabolism. With a total of four patents to his name, Duverger's work has the potential to impact the treatment of various diseases.

Latest Patents

One of Duverger's latest patents involves a regulatory nucleic acid for the ABC1 gene. This invention focuses on a nucleic acid capable of regulating the transcription of the ABC1 gene, which is linked to pathologies related to cholesterol metabolism dysfunction, such as atherosclerosis. The patent also includes nucleotide constructs that encode a polypeptide or a nucleic acid of interest, controlled by the regulatory nucleic acid for the ABC1 gene. Additionally, it covers recombinant vectors, transformed host cells, and nonhuman transgenic mammals that incorporate this nucleic acid, along with methods for screening molecules that can modify the activity of the regulatory nucleic acid.

Another significant patent is for a transgenic rabbit that expresses a functional human lipoprotein (a). This rabbit contains genomic DNA sequences encoding apolipoprotein (a) and apolipoprotein B polypeptides, which can combine to produce lipoprotein (a). The patent outlines the process for creating such a rabbit and its use in identifying compounds effective in treating human diseases associated with Lp(a) expression.

Career Highlights

Throughout his career, Duverger has worked with notable companies in the pharmaceutical industry, including Aventis Pharmaceuticals Inc. and Rhône-Poulenc Rorer S.A. His experience in these organizations has contributed to his expertise in biotechnology and patent development.

Collaborations

Duverger has collaborated with esteemed colleagues such as Patrice Denefle and Patrick Benoit. These partnerships have likely enhanced his research and innovation efforts in the field.

Conclusion

Nicolas Duverger's contributions to biotechnology through his patents and collaborations highlight his role as an influential inventor. His work on gene regulation and transgenic models holds promise for advancing medical treatments related to cholesterol metabolism and associated diseases.