The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 27, 2008
Filed:
May. 02, 2001
Marie-françoise Rosier-montus, Antony, FR;
Catherine Prades, Thais, FR;
Cendrine Lemoine, Massy, FR;
Laurent Naudin, Etampes, FR;
Patrice Denefle, Saint Maur, FR;
Nicolas Duverger, Paris, FR;
Bryan Brewer, Potomac, MD (US);
Alan Remaley, Bethesda, MD (US);
Sylvia Santamarina-fojo, Potomac, MD (US);
Marie-Françoise Rosier-Montus, Antony, FR;
Catherine Prades, Thais, FR;
Cendrine Lemoine, Massy, FR;
Laurent Naudin, Etampes, FR;
Patrice Denefle, Saint Maur, FR;
Nicolas Duverger, Paris, FR;
Bryan Brewer, Potomac, MD (US);
Alan Remaley, Bethesda, MD (US);
Sylvia Santamarina-Fojo, Potomac, MD (US);
Aventis Pharma S.A., Antony, FR;
Abstract
The present invention concerns a nucleic acid which is capable of regulating the transcription of the ABC1 gene, which is a causal gene for pathologies linked to a dysfunctioning of cholesterol metabolism, inducing diseases such as atherosclerosis. The invention also relates to nucleotide constructs comprising a polynucleotide which encodes a polypeptide or a nucleic acid of interest, placed under the control a regulatory nucleic acid for the ABC1 gene. The invention also relates to recombinant vectors, transformed host cells and nonhuman transgenic mammals comprising a nucleic acid which regulates the transcription of the ABC1 gene or an abovementioned nucleotide construct, as well as methods for screening molecules or substances which are capable of modifying the activity of the regulatory nucleic acid for the ABC1 gene.