Company Filing History:
Years Active: 2000-2002
Title: Naokazu Naitoh: Innovator in Human Growth Hormone Production
Introduction
Naokazu Naitoh is a prominent inventor based in Chiba, Japan. He has made significant contributions to the field of biotechnology, particularly in the production of human growth hormone. With a total of 3 patents to his name, Naitoh's work has paved the way for advancements in medical and pharmaceutical applications.
Latest Patents
Naitoh's latest patents focus on methods for the secretory production of human growth hormone (hGH). One of his notable inventions involves a DNA encoding 20K hGH that is directly connected to a gene encoding the OppA protein secretion signal, along with a DNA encoding signal peptidase 1. This innovative approach allows for the construction of a recombinant plasmid, which is then transformed into cells. The resulting transformant strain is cultured for the efficient secretory production of 20K hGH in the periplasm. This method not only enhances the production efficiency of 20K hGH but also simplifies the isolation and purification process due to the low level of impure proteins present in the periplasm fraction.
Another patent by Naitoh describes a similar method using Escherichia coli. In this case, the DNA encoding 20K hGH is connected to the OppA protein secretion signal and signal peptidase 1 to create a recombinant plasmid. E. coli is transformed with this plasmid, and the cells are cultured for the secretory production of 20K hGH in the E. coli periplasm. This method also ensures efficient production and easy purification of the hormone.
Career Highlights
Naitoh is currently associated with Mitsui Chemicals, Inc., where he continues to innovate in the field of biotechnology. His work has been instrumental in enhancing the production processes of important biological compounds.
Collaborations
Throughout his career, Naitoh has collaborated with esteemed colleagues such as Masaru Honjo and Hiroshi Uchida. These collaborations have further enriched his research and contributed to the advancements in the field.
Conclusion
Naokazu Naitoh's contributions to the production of human growth hormone through innovative methods have made a significant impact in biotechnology. His patents reflect a commitment to improving efficiency and purity in hormone production, showcasing his role as a