Nanda Dulal Sinha

Title: Nanda Dulal Sinha: Innovator in Oligonucleotide Preparation

Introduction

Nanda Dulal Sinha is a notable inventor based in Milford, MA (US). He has made significant contributions to the field of biotechnology, particularly in the preparation of oligonucleotides. With a total of 8 patents to his name, Sinha's work has advanced the understanding and application of oligonucleotide synthesis.

Latest Patents

Among his latest patents is an innovative oxidation process for the preparation of an oligonucleotide that features at least one phosphate internucleotide linkage. This process involves several steps that enhance the efficiency and effectiveness of oligonucleotide synthesis. Another significant patent focuses on the preparation of poly(alkoxylated) oligonucleotides. This process entails reacting a purified oligonucleotide with a poly(alkoxide), allowing for the formation of a poly(alkoxylated) oligonucleotide. The separation of this compound from non-poly(alkoxylated) oligonucleotides can be achieved through ultrafiltration under denaturing conditions, utilizing various methods such as organic solvents, urea, chaotropic salts, formamide, and heat.

Career Highlights

Nanda Dulal Sinha is currently associated with Avecia Biotechnology, Inc., where he continues to innovate in the field of biotechnology. His work has not only contributed to the scientific community but has also paved the way for advancements in therapeutic applications.

Collaborations

Sinha has collaborated with notable colleagues, including William Edward Zedalis and Gregory Keith Miranda. These partnerships have fostered a collaborative environment that enhances research and development in their respective fields.

Conclusion

Nanda Dulal Sinha's contributions to biotechnology, particularly in oligonucleotide preparation, highlight his role as an influential inventor. His patents reflect a commitment to advancing scientific knowledge and practical applications in the industry.