The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 10, 2012
Filed:
Oct. 06, 2008
Applicants:
Nanda Sinha, Boxboro, MA (US);
William Edward Zedalis, Fitchburg, MA (US);
Gregory Keith Miranda, Princeton, MA (US);
Inventors:
Nanda Sinha, Boxboro, MA (US);
William Edward Zedalis, Fitchburg, MA (US);
Gregory Keith Miranda, Princeton, MA (US);
Assignee:
Avecia Biotechnology, Inc., Milford, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 275/06 (2006.01);
U.S. Cl.
CPC ...
Abstract
A process for the synthesis of oligonucleotides using phosphoramidite chemistry is provided. The process employs as activator a 1,1-dioxo-1,2-dihydro-1λ-benzo[d]isothiazol-3-one, preferably in the presence of an organic base. The 1,1-dioxo-1,2-dihydro-1λ-benzo[d]isothiazol-3-one is represented by the following structural formula: