Company Filing History:
5 out of 97 
4 out of 2,099 
Years Active: 2013-2017
Title: The Innovative Contributions of Nancy Maizels
Introduction
Nancy Maizels is a prominent inventor based in Seattle, WA, known for her significant contributions to the field of biotechnology. With a total of eight patents to her name, she has made remarkable advancements in the understanding and manipulation of genetic processes. Her work primarily focuses on the mutagenesis of target genes and the development of therapeutic antibodies.
Latest Patents
One of her latest patents is titled "Inducible mutagenesis of target genes." This invention relates to the mutagenesis of target genes that leverages the natural mutagenic capabilities of B cells. It enhances these capabilities by controlling the diversification process. The method allows for the rapid and inducible generation of point mutations and other types of diversification in expressed genes, particularly antibody genes. This innovation can be coupled with selection processes to identify B cell clones that produce antibodies with high affinity or specificity. The diversification process is both inducible and reversible, providing a means for the rapid development of a repertoire of variant immunoglobulins and other polypeptides.
Another significant patent is "Anti-FZD10 monoclonal antibodies and methods for their use." This invention focuses on anti-FZD10 antibodies and their applications. The antibodies are useful for altering various cellular processes, including survival, replication, differentiation, and epithelial-to-mesenchymal cell transition of embryonic stem cells. They also hold potential for treating diseases associated with the expression of FZD10, including various cancers, either as standalone therapies or in combination with other agents.
Career Highlights
Nancy Maizels has had a distinguished career, working with notable organizations such as Omeros Corporation and the University of Washington. Her work in these institutions has allowed her to collaborate with leading experts in her field and contribute to groundbreaking research.
Collaborations
Some of her notable coworkers include W Jason Cummings and Munehisa Yabuki. Their collaborative efforts have further advanced the research and applications of her inventions.
Conclusion
Nancy Maizels is a trailblazer in the field of biotechnology, with her innovative patents paving the way for new therapeutic approaches. Her contributions to mutagenesis and antibody development are invaluable to the scientific community and hold promise for future medical advancements.
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