Company Filing History:
19 out of 349 
1 out of 3,685 
5 out of 832,718 Years Active: 1990-2004
Title: Innovations of Monroe E. Wall in Anti-Tumor Compounds
Introduction
Monroe E. Wall, a distinguished inventor based in Chapel Hill, NC, is renowned for his significant contributions to the field of medicinal chemistry, particularly in the development of anti-tumor compounds. With an impressive portfolio of 23 patents, Wall has made substantial strides in cancer treatment through innovative chemical constructs.
Latest Patents
Among his latest patents, Wall has focused on groundbreaking advancements in camptothecin compounds. One notable patent details camptothecin compounds with a thioether group, which have shown effectiveness as anti-tumor agents. These conjugates are designed to inhibit the enzyme topoisomerase I and enhance the stability of the topoisomerase I-DNA cleavable complex, a critical target in cancer therapy. Additionally, Wall has developed camptothecin β-alanine esters that also inhibit topoisomerase I, potentially leading to DNA alkylation of the associated topoisomerase I-DNA cleavable complex. These patents reflect Wall's commitment to improving cancer treatment methodologies.
Career Highlights
Throughout his career, Monroe E. Wall has held key positions in various research organizations, notably at the Research Triangle Institute. His extensive research and innovative mindset have allowed him to contribute significantly to the field of anti-cancer drug development, resulting in a wealth of recognized patents.
Collaborations
Wall's impactful work has been bolstered by collaborations with esteemed colleagues, including Mansukh C. Wani and Govindarajan Manikumar. These partnerships have fostered a dynamic environment for sharing knowledge and expertise, leading to progressive breakthroughs in the pharmaceutical industry.
Conclusion
Monroe E. Wall's innovations in anti-tumor compounds showcase his dedication to advancing cancer treatment through chemical innovation. With his robust patent portfolio and collaborative approach, Wall continues to influence the future of medicinal chemistry and the development of effective therapeutic agents.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.