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For the Inventor, By the Inventor

Chapel Hill, NC, United States of America

Monroe E Wall

This inventor holds 23 USPTO granted patents, primarily in Camptothecin Compounds. Top assignees: Research Triangle Institute, Johns Hopkins University, Other. Active years: 1990-2004.

IDiyas Innovation Intelligence. (2026). Inventor Profile: Monroe E Wall. Retrieved from https://idiyas.com/inventor/monroe-e-wall

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

USPTO Granted Patents = 23

% Patents Active = 100.0

Average Co-Inventor Count = 3.2

ph-index = 13

Forward Citations = 522(Granted Patents)


Company Filing History:

goldMedal19 out of 359 
 
Research Triangle Institute
 patents
silverMedal1 out of 3,801 
 
Johns Hopkins University
 patents
bronzeMedal5 out of 834,513 
Other
 patents
where one patent can have more than one assignee

Years Active: 1990-2004

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Areas of Expertise:
Camptothecin
Topoisomerase I
Inhibition
Pharmaceutical Compositions
Water-Soluble Esters
Anti-Tumor
Synthesis
Analog Compounds
Fluoromethylenedioxy
Alkyl Compounds
Tumor Treatment
Plasmodia Parasites
23 patents (USPTO):Explore Patents
1. 6825206 - Camptothecin compounds with a thioether group (2004-11-30),
2. 6288072 - Camptothecin &bgr;-alanine esters with topoisomerase I inhibition (2001-09-11),
3. 6268375 - 10, 11-difluoromethylenedioxycamptothecin compounds with topoisomerase I inhibition (2001-07-31),
4. 6040313 - Water-soluble esters of camptothecin compounds (2000-03-21),
5. 5985888 - Camptothecin compounds with combined topoisomarase I inhibition and DNA (1999-11-16),
6. 5932588 - Camptothecin compounds with combined topoisomerase I inhibition and DNA (1999-08-03),
7. 5916896 - Water-soluble esters of camptothecin compounds (1999-06-29),
8. 5646159 - Water-soluble esters of camptothecin compounds (1997-07-08),
9. 5614529 - Inhibition of plasmodia parasites by camptothecin compounds (1997-03-25),
10. 5496830 - Inhibition of hemoflagellates by camptothecin compounds (1996-03-05),
11. 5401747 - Alkyl camptothecin compounds as potent inhibitors of human colorectal (1995-03-28),
12. 5364858 - Camptothecin analogs as potent inhibitors of topoisomerase I (1994-11-15),
13. 5340817 - Method of treating tumors with anti-tumor effective camptothecin (1994-08-23),
14. 5244903 - Camptothecin analogs as potent inhibitors of topoisomerase I (1993-09-14),
15. 5227380 - Pharmaceutical compositions and methods employing camptothecins (1993-07-13),

Title: Innovations of Monroe E. Wall in Anti-Tumor Compounds

Introduction

Monroe E. Wall, a distinguished inventor based in Chapel Hill, NC, is renowned for his significant contributions to the field of medicinal chemistry, particularly in the development of anti-tumor compounds. With an impressive portfolio of 23 patents, Wall has made substantial strides in cancer treatment through innovative chemical constructs.

Latest Patents

Among his latest patents, Wall has focused on groundbreaking advancements in camptothecin compounds. One notable patent details camptothecin compounds with a thioether group, which have shown effectiveness as anti-tumor agents. These conjugates are designed to inhibit the enzyme topoisomerase I and enhance the stability of the topoisomerase I-DNA cleavable complex, a critical target in cancer therapy. Additionally, Wall has developed camptothecin β-alanine esters that also inhibit topoisomerase I, potentially leading to DNA alkylation of the associated topoisomerase I-DNA cleavable complex. These patents reflect Wall's commitment to improving cancer treatment methodologies.

Career Highlights

Throughout his career, Monroe E. Wall has held key positions in various research organizations, notably at the Research Triangle Institute. His extensive research and innovative mindset have allowed him to contribute significantly to the field of anti-cancer drug development, resulting in a wealth of recognized patents.

Collaborations

Wall's impactful work has been bolstered by collaborations with esteemed colleagues, including Mansukh C. Wani and Govindarajan Manikumar. These partnerships have fostered a dynamic environment for sharing knowledge and expertise, leading to progressive breakthroughs in the pharmaceutical industry.

Conclusion

Monroe E. Wall's innovations in anti-tumor compounds showcase his dedication to advancing cancer treatment through chemical innovation. With his robust patent portfolio and collaborative approach, Wall continues to influence the future of medicinal chemistry and the development of effective therapeutic agents.

Profile summary based on public USPTO records.
Data Sources: USPTO Patent Grant XML, Patent Center, EPO & CIPO • Normalized by IDiyas Innovation Graph. Methodology & provenance architecturePlease report any incorrect information to [email protected]
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