The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 11, 2001
Filed:
Dec. 29, 1999
Applicant:
Inventors:
Monroe E. Wall, Chapel Hill, NC (US);
Mansukh C. Wani, Durham, NC (US);
Govindarajan Manikumar, Raleigh, NC (US);
Neelakantan Balasubramanian, Madison, CT (US);
Dolatrai Vyas, Madison, CT (US);
Assignee:
Other;
Primary Examiner:
Int. Cl.
CPC ...
C07D / ; C07D / ; A61K 3/1444 ; A61K 3/1443 ;
U.S. Cl.
CPC ...
C07D / ; C07D / ; A61K 3/1444 ; A61K 3/1443 ;
Abstract
&bgr;-Alanine esters of camptothecin compounds which are effective anti-tumor compounds are disclosed. These compounds inhibit the enzyme topoisomerase I and may alkylate DNA of the associated topoisomerase I-DNA cleavable complex.