The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 13, 1993
Filed:
Dec. 31, 1990
Applicant:
Inventors:
Monroe E Wall, Chapel Hill, NC (US);
Mansukh C Wani, Durham, NC (US);
Allan W Nicholas, Raleigh, NC (US);
Govindarajan Manikumar, Raleigh, NC (US);
Assignee:
Research Triangle Institute, Research Triangle Park, NC (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; C07D / ; C07D / ;
U.S. Cl.
CPC ...
514253 ; 514283 ; 544361 ; 546 41 ; 546 48 ;
Abstract
A method for synthesizing camptothecin and camptothecin analogs using a novel hydroxyl-containing tricyclic intermediate and the camptothecin analogs produced by the process. The camptothecin analogs are effective inhibitors of topoisomerase I and show antileukemic and anti-tumor activity.