Minghuang Zhang

Title: The Innovations of Minghuang Zhang

Introduction

Minghuang Zhang is a notable inventor based in Gaithersburg, MD (US). He has made significant contributions to the field of molecular biology, particularly in the study of gene expression and its implications in cancer research. With a total of 4 patents, his work has garnered attention for its potential applications in medical science.

Latest Patents

Zhang's latest patents include the cDNA encoding a gene known as BOG (B5T Over-expressed Gene) and its protein product. This invention provides nucleic acids that encode novel polypeptides designated as 'BOG'. The BOG protein binds to pRb and is over-expressed in several transformed rat liver epithelial (RLE) cell lines that are resistant to the growth inhibitory effects of TGF-β1, as well as in primary liver tumors. His patents also cover compositions that include BOG chimeras, nucleic acids encoding BOG, and antibodies to BOG. Furthermore, methods of using BOG to modulate pRb-protein interactions and alter cellular phenotypes are also detailed in his patents.

Career Highlights

Throughout his career, Minghuang Zhang has worked with prestigious organizations such as the National Institutes of Health, a component of the US Department of Health & Human Services, and The Picower Institute for Medical Research. His work in these institutions has allowed him to advance his research and contribute to significant scientific discoveries.

Collaborations

Zhang has collaborated with notable colleagues, including Kevin J. Tracey and Snorri S. Thorgeirsson. These collaborations have further enriched his research and expanded the impact of his inventions.

Conclusion

Minghuang Zhang's innovative work in gene expression and cancer research highlights his importance as an inventor in the scientific community. His patents and collaborations reflect a commitment to advancing medical science and improving therapeutic strategies.