The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 11, 2008
Filed:
Feb. 05, 2004
Snorri S. Thorgeirsson, Bethesda, MD (US);
Joseph T. Woitach, North Bethesda, MD (US);
Minghuang Zhang, Gaithersburg, MD (US);
Snorri S. Thorgeirsson, Bethesda, MD (US);
Joseph T. Woitach, North Bethesda, MD (US);
Minghuang Zhang, Gaithersburg, MD (US);
Abstract
Nucleic acids that encode novel polypeptides, designated in the present application as 'BOG' (B5T Over-expressed Gene) are provided. BOG binds to pRb and is over-expressed in a number transformed rat liver epithelial (RLE) cell lines resistant to the growth inhibitory effect of TGF-β1 as well as in primary liver tumors. Compositions including BOG chimeras, nucleic acids encoding BOG and antibodies to BOG are also provided. Methods of using BOG to modulate pRb-protein interactions and to alter cellular phenotype are further provided.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile