National Institutes of Health, a Component of the US Dept. of Health & Human Services

North Shore-long Island Jewish Research Institute

The Picower Institut for Medical Research

Minghuang Zhang

Kevin J Tracey

Snorri S Thorgeirsson

Joseph T Woitach

Nucleic acids that encode novel polypeptides, designated in the present application as 'BOG' (B5T Over-expressed Gene) are provided. BOG binds to pRb and is over-expressed in a number transformed rat liver epithelial (RLE) cell lines resistant to the growth inhibitory effect of TGF-&#x3b2;1 as well as in primary liver tumors. Compositions including BOG chimeras, nucleic acids encoding BOG and antibodies to BOG are also provided. Methods of using BOG to modulate pRb-protein interactions and to alter cellular phenotype are further provided.

cDNA encoding a gene BOG (B5T over-expressed gene) and its protein product

Nucleic acids that encode novel polypeptides, designated in the present application as &ldquo;BOG&rdquo; (B5T ver-expressed ene) are provided. BOG binds to pRb and is over-expressed in a number transformed rat liver epithelial (RLE) cell lines resistant to the growth inhibitory effect of TGF-&bgr;1 as well as in primary liver tumors. Compositions including BOG chimeras, nucleic acids encoding BOG and antibodies to BOG are also provided. Methods of using BOG to modulate pRb-protein interactions and to alter cellular phenotype are further provided.

cDNA encoding a gene BOG (B5T Over-expressed Gene) and its protein product

There is disclosed a class of pharmaceutical compositions useful for the treatment of cancer, particularly solid tumors, and having a mechanism of action as spermine antagonists. The present pharmaceutical compositions are able to inhibit the inhibitory effect of spermine upon macrophage function, and thus prevent spermine-induced immunosuppression.

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Gaithersburg, MD, United States of America

Minghuang Zhang