Company Filing History:
Years Active: 1988-1995
Title: Milton M Mozen: Innovator in Immunoglobulin Preparation
Introduction
Milton M Mozen is a notable inventor based in Berkeley, CA, recognized for his significant contributions to the field of immunology. He holds a total of 4 patents that focus on the preparation of human immunoglobulin and virus-free antibodies. His work has had a profound impact on the safety and efficacy of therapeutic immunoglobulin preparations.
Latest Patents
One of Mozen's latest patents involves the preparation of human immunoglobulin free of hepatitis C. This patent details the effects of Cohn-Oncley cold alcohol fractionation on the infectivity of two prototype retroviruses, specifically mouse xenotropic type C and the LAV strain of AIDS retrovirus. The research indicates a significant reduction in retrovirus titer, achieving at least a 100,000-fold reduction of LAV when fractionating plasma to fraction II. Furthermore, adjustments to pH 4.0 at filtrate III were found to be as effective for viral inactivation as precipitation of fraction II from filtrate III with 25% ethanol. Liquid immunoglobulin preparations spiked with LAV and incubated at 27°C for three days resulted in an additional 1,000-10,000-fold reduction of LAV titer. These findings support the clinical evidence that therapeutic immunoglobulin preparations processed by Cohn-Oncley cold ethanol processing do not transmit retroviruses such as the LAV strain of the AIDS virus. Another patent focuses on the preparation of virus-free antibodies, which can be made substantially free of infectious viruses by storing them under specific conditions of pH, temperature, and time.
Career Highlights
Throughout his career, Milton Mozen has worked with prominent companies such as Miles Laboratories, Inc. and Miles Inc. His innovative approaches have contributed to advancements in the field of immunology and have paved the way for safer therapeutic options.
Collaborations
Mozen has collaborated with notable individuals in his field, including Gautam Mitra and Robert E Louie. These collaborations have further enhanced the impact of his research and inventions.
Conclusion
Milton M Mozen's work in the preparation of human immunoglobulin and virus-free antibodies has made significant strides in immunology. His patents reflect a commitment to improving the safety of therapeutic treatments, showcasing his role