Michael William Pennington

Title: Innovations of Michael William Pennington

Introduction

Michael William Pennington is a notable inventor based in Mount Laurel, NJ (US). He has made significant contributions to the field of biochemistry, particularly in the development of analogs of ShK toxin. With a total of five patents to his name, Pennington's work focuses on selective inhibition of potassium channels, which has important implications for treating various diseases and disorders.

Latest Patents

Among his latest patents are "Analogs of ShK toxin and their uses in selective inhibition of Kv1.3 potassium channels" and "Analogs of ShK toxin and methods for using such ShK analogs." These patents describe ShK analogs that consist of ShK toxin attached to a chemical entity with an anionic charge. The ShK analogs can be administered to both human and non-human animal subjects to inhibit potassium channels or to treat specific diseases. Notably, the chemical entity can be selected to provide selective inhibition of certain potassium channels, such as Kv1.3 channels, over others like Kv1.1 channels. Additionally, some embodiments include a fluorophore, allowing these analogs to be utilized in flow cytometry, either alone or in conjunction with class II tetramers that detect autoreactive cells.

Career Highlights

Pennington has worked with prestigious institutions, including the University of California and Intrinsic Lifesciences LLC. His experience in these organizations has contributed to his expertise in the field of biochemistry and the development of innovative solutions for medical applications.

Collaborations

Throughout his career, Pennington has collaborated with notable colleagues such as Christine Beeton and George Chandy. These partnerships have likely enhanced his research and development efforts, leading to impactful innovations in his field.

Conclusion

Michael William Pennington's work in developing ShK toxin analogs represents a significant advancement in the selective inhibition of potassium channels. His contributions to biochemistry and collaboration with esteemed colleagues highlight his role as an influential inventor in the medical research community.