The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 25, 2010
Filed:
Apr. 28, 2005
Xavier Lauth, San Diego, CA (US);
Mark E. Westerman, San Diego, CA (US);
Vaughn E. Ostland, La Quinta, CA (US);
Jason A. Stannard, San Diego, CA (US);
Michael W. Pennington, Mount Laurel, NJ (US);
Xavier Lauth, San Diego, CA (US);
Mark E. Westerman, San Diego, CA (US);
Vaughn E. Ostland, La Quinta, CA (US);
Jason A. Stannard, San Diego, CA (US);
Michael W. Pennington, Mount Laurel, NJ (US);
Intrinsic Lifesciences, La Jolla, CA (US);
Abstract
The present invention concerns a method for the oxidative refolding of a hepcidin polypeptide to a form that is mature, bioactive and folded as in the native configuration and molecular mass; a method for measuring the level of native, bioactive hepcidin in a vertebrate animal; a method for measuring the level of hepcidin gene expression in a vertebrate animal; and a method for regulating the production of native, bioactive hepcidin in a vertebrate animal in vivo. The present invention also concerns an antibody or fragment thereof that specifically binds to a continuous, discontinuous, and/or conformational epitope of a mature and bioactive hepcidin folded as in the native configuration; and a pharmaceutical composition that includes the antibody or a hepcidin polypeptide and that provides antimicrobial, agonistic, or antagonistic activities in vivo in a vertebrate animal.