Michael Ryckelynck

Title: A Spotlight on Inventor Michael Ryckelynck: Innovations in RNA Aptamers and Molecular Target Capture

Introduction

Michael Ryckelynck, a prominent inventor based in Strasbourg, France, has made significant contributions to the fields of biochemistry and molecular biology. With two patents to his name, he has advanced our understanding of RNA aptamers and innovative methods for molecular target capture.

Latest Patents

Ryckelynck's latest inventions include noteworthy advancements in the realm of RNA aptamers. His first patent, titled "Fluorogen-binding RNA aptamers," introduces RNA aptamers with unique fluorescent properties. These aptamers exhibit distinct fluorophore binding affinities and a remarkable dependency on salt conditions. The patent also describes corresponding fluorophores, with select variants demonstrating high cellular permeability. The high affinities for fluorophores, alongside the exceptional brightness of the bound complexes and their thermal and salt stability, highlight the innovative aspects of these disclosed aptamers.

In his second patent, "Intra-droplet surface engineering to capture a molecular target," Ryckelynck presents a method for capturing a molecular target found in the aqueous phase of a water-in-oil emulsion. This method employs a binding system that includes a surfactant with a functional moiety on its hydrophilic head and a chemoprobe acting as a molecular staple between the surfactant and the molecular target. The chemoprobe is designed with two distinct domains, one for specifically binding the target and the other to interact with the surfactant either through covalent or non-covalent means.

Career Highlights

Michael Ryckelynck has had a distinguished career, aligning himself with renowned institutions such as the University of Strasbourg and the National Center for Scientific Research (Centre National De La Recherche Scientifique). His work in these prestigious environments has allowed him to refine his research and innovate in significant ways.

Collaborations

Throughout his career, Ryckelynck has collaborated with notable colleagues, including Alain Wagner and Sylvain Ursuegui. These partnerships underscore the importance of collaborative efforts in advancing scientific knowledge and innovation.

Conclusion

Michael Ryckelynck’s contributions to the field of biochemistry illustrate the critical role of inventors in pushing the boundaries of science. Through his patents on RNA aptamers and molecular target capture methods, he has paved the way for new research possibilities and applications, reinforcing the importance of innovation in modern science.