Company Filing History:
Years Active: 2020-2023
Title: Michael Meldgaard: Innovator in Oligonucleotide Conjugation
Introduction
Michael Meldgaard is a prominent inventor based in Hørsholm, Denmark. He has made significant contributions to the field of oligonucleotide conjugates, holding a total of 3 patents. His work focuses on improving the efficiency of oligonucleotide synthesis and cleavage processes.
Latest Patents
One of his latest patents is the "Oligonucleotide conjugation process." This invention relates to methods of synthesizing oligonucleotide conjugates in a low-water content solvent environment. This innovative approach allows for more efficient conjugation, reducing the amount of conjugate moiety needed and increasing the speed of the conjugation reaction. Another notable patent is "Rapid unylinker cleavage," which describes methods for cleaving oligonucleotides from a solid support. This method involves treating the bound oligonucleotide with a concentrated ammonium hydroxide solution for a specified duration, utilizing a LNA nucleoside for enhanced results.
Career Highlights
Michael Meldgaard is currently associated with Roche Innovation Center Copenhagen A/S, where he continues to advance research in oligonucleotide technologies. His expertise and innovative approaches have positioned him as a key figure in this specialized field.
Collaborations
Throughout his career, Michael has collaborated with notable colleagues, including Dennis Jul Hansen and Christoph Rosenbohm. These partnerships have fostered a collaborative environment that enhances the development of cutting-edge technologies.
Conclusion
Michael Meldgaard's contributions to the field of oligonucleotide conjugation are noteworthy, with his innovative patents paving the way for advancements in synthesis and cleavage methods. His work continues to impact the scientific community positively.