The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 03, 2023
Filed:
Mar. 22, 2018
Applicant:
Roche Innovation Center Copenhagen A/s, Horsholm, DK;
Inventors:
Michael Meldgaard, Hørsholm, DK;
Marianne B. Mogensen, Hørsholm, DK;
Dennis Jul Hansen, Hørsholm, DK;
Assignee:
Roche Innovation Center Copenhagen A/S, Horsholm, DK;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/00 (2006.01); C07H 1/00 (2006.01); C07H 1/06 (2006.01);
U.S. Cl.
CPC ...
C07H 21/00 (2013.01); C07H 1/00 (2013.01); C07H 1/06 (2013.01);
Abstract
Methods for cleaving oligonucleotides from a solid support are described as are methods for synthesizing an oligonucleotide on a solid support and subsequently cleaving the oligonucleotide from the solid support. In the methods, the 3' nucleoside of the oligonucleotide attached to the solid support is a LNA nucleoside. The method entail treating the bound oligonucleotide with a concentrated ammonium hydroxide solution for about 30 minutes to about 6 hours.