This inventor holds 3 USPTO granted patents and 1 EPO patent. Top assignee: California Institute of Technology. Active years: 2008-2013.
Company Filing History:
Years Active: 2008-2013
Title: Michael Marques: Innovator in DNA Recognition Technologies
Introduction
Michael Marques is a prominent inventor based in San Mateo, CA (US). He has made significant contributions to the field of DNA recognition technologies, holding a total of 3 patents. His work focuses on developing novel methods and compositions that enhance the understanding and manipulation of DNA sequences.
Latest Patents
One of Marques' latest patents is titled "Alternative heterocycles for DNA recognition." This patent provides methods and compositions for forming complexes between double-stranded DNA (dsDNA) and novel oligomers that comprise fused six-membered rings. By selecting appropriate target sequences and oligomers, these complexes can achieve high association constants. The formation of these complexes has potential applications in identifying specific dsDNA sequences, inhibiting gene transcription, and serving as therapeutics for controlling the proliferation of undesired cells or modulating the expression of specific genes.
Another significant patent by Marques is "DNA-binding polymers." This invention outlines methods and compositions for creating complexes between dsDNA and innovative DNA-binding polymers that include N-terminal thiophene-containing moieties, which exhibit selectivity for T-A base pairs. Similar to his previous work, the appropriate choice of target sequences and DNA-binding polymers allows for the formation of complexes with high association constants. These complexes can also be utilized for identifying specific dsDNA sequences, inhibiting gene transcription, and as therapeutic agents.
Career Highlights
Michael Marques is affiliated with the California Institute of Technology, where he continues to advance research in DNA technologies. His innovative approaches have positioned him as a key figure in the field, contributing to both academic and practical applications of DNA manipulation.
Collaborations
Throughout his career, Marques has collaborated with notable colleagues, including Peter B Dervan and Raymond Doss. These partnerships have further enriched his research and expanded the impact of his inventions.
Conclusion
Michael Marques is a distinguished inventor whose work in DNA recognition technologies has led to significant advancements in the field. His patents reflect a commitment to innovation and the potential for therapeutic applications in genetics.