The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 18, 2008
Filed:
Jan. 18, 2005
Peter B. Dervan, San Marino, CA (US);
Shane Foister, Philadelphia, PA (US);
Raymond Doss, Clark, NJ (US);
Michael A. Marques, San Mateo, CA (US);
Peter B. Dervan, San Marino, CA (US);
Shane Foister, Philadelphia, PA (US);
Raymond Doss, Clark, NJ (US);
Michael A. Marques, San Mateo, CA (US);
California Institute of Technology, Pasadena, CA (US);
Abstract
Methods and compositions are provided for forming complexes between dsDNA and novel DNA-binding polymers comprising N-terminal thiophene-containing moieties which exhibit selectivity for T-A base pairs. By appropriate choice of target sequences and DNA-binding polymers, complexes comprising polymer-DNA are obtained with high association constants. The formation of complexes can be used for identification of specific dsDNA sequences, for inhibiting gene transcription, and as a therapeutic for inhibiting proliferation of undesired cells or modulation of expression of specific genes.