Company Filing History:
3 out of 3,923 
2 out of 1,187 
Years Active: 2008
Title: Michael Joseph Kadan: Innovator in Gene Therapy
Introduction
Michael Joseph Kadan is a prominent inventor based in Adamstown, MD (US), known for his significant contributions to the field of gene therapy. With a total of three patents to his name, Kadan has made remarkable advancements in the development of transcriptional regulators and molecular gene switches.
Latest Patents
Kadan's latest patents include innovative fusion proteins designed as ligand-dependent transcriptional regulators. These proteins consist of a nucleotide binding domain linked to a ligand-binding domain, which can also incorporate a transcription regulating domain. The nucleotide binding domain is a zinc-finger peptide that specifically binds to a targeted nucleotide sequence ranging from 3 to about 18 nucleotides, making these fusion proteins valuable for gene therapy applications. Additionally, he has developed polynucleotides encoding these fusion proteins, expression vectors, and transfected cells. Another notable patent involves mutants of steroid receptor ligand binding domains and synthetic ligands that exhibit specific binding affinities for these receptors. This invention facilitates the construction of selective 'molecular gene switches' and outlines methods for regulating gene function using these switches.
Career Highlights
Throughout his career, Kadan has worked with esteemed organizations such as Novartis AG and The Scripps Research Institute, where he has honed his expertise in molecular biology and gene therapy.
Collaborations
Kadan has collaborated with notable