The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 28, 2008
Filed:
Apr. 23, 2003
Carlos F. Barbas, Iii, Del Mar, CA (US);
Michael Joseph Kadan, Adams Town, MD (US);
Roger Beerli, San Diego, CA (US);
Carlos F. Barbas, III, Del Mar, CA (US);
Michael Joseph Kadan, Adams Town, MD (US);
Roger Beerli, San Diego, CA (US);
The Scripps Research Institute, La Jolla, CA (US);
Novartis AG, Basel, CH;
Abstract
Fusion proteins for use as ligand-dependent transcriptional regulators are provided. The fusion proteins include a nucleotide binding domain operatively linked to a ligand-binding domain. They also can include a transcription regulating domain. The nucleotide binding domain is a zinc-finger peptide that binds to a targeted contiguous nucleotide sequence of from 3 to about 18 nucleotides are provided. The fusion proteins are used for gene therapy. Also provided are polynucleotides encoding the fusion proteins, expression vectors, and transfected cells.