Michael John Parnham

Title: **Michael John Parnham: Innovator in Pain Management and Organ Failure Treatment**

Introduction

Michael John Parnham is a notable inventor based in Bad Soden am Taunus, Germany, recognized for his significant contributions to medical science through his innovative patents. With a total of eight patents to his name, Parnham has made remarkable advances in the treatment of neuropathic pain and organ failure, particularly in the context of chemotherapy and sepsis.

Latest Patents

Two of Parnham's most recent and impactful patents include:

1. **CYP2J2 antagonists in the treatment of pain** - This patent focuses on novel treatments for neuropathic pain, specifically chemotherapy-induced peripheral neuropathic pain (CIPNP). The invention presents antagonists of cytochrome P450 epoxygenases (CYP), particularly CYP2J2, as therapeutic agents that alleviate CIPNP. By reducing chemotherapeutic-induced pain, these antagonists enable higher dosing during cancer treatments. The invention also explores the use of CYP2J2 agonists or metabolites to sensitize TRPV1, aiming to address disorders responsive to TRPV1 agonists.

2. **B7-H1 fusion polypeptides for treating and preventing organ failure** - This patent involves a fusion polypeptide designed to treat or prevent organ failure in subjects suffering from sepsis. It comprises a Fc portion of an immunoglobulin and the extracellular portion of the human B7-H1 polypeptide. Additionally, it encompasses a polynucleotide encoding the said fusion polypeptide for therapeutic applications in sepsis-related organ failure.

Career Highlights

Michael John Parnham is associated with the Fraunhofer Society for the Advancement of Applied Research, a leading research institution in Germany. His work in the society is characterized by a commitment to innovative solutions and enhances the fight against severe medical conditions.

Collaborations

Throughout his career, Parnham has collaborated with esteemed colleagues, including Andreas Von Knethen and Lisa Katharina Sha. These partnerships have facilitated the exchange of ideas and contributed to his groundbreaking research and development in the field of medicine.

Conclusion

Michael John Parnham stands out as a pioneering inventor, whose work in developing effective treatments for neuropathic pain and organ failure exemplifies the power of innovation in medicine. With his multiple patents, he continues to impact the lives of patients through improved therapeutic options. His contributions reflect the importance of research and collaboration in advancing healthcare solutions.