Vacaville, CA, United States of America

Michael J McCulloch


Average Co-Inventor Count = 4.6

ph-index = 11

Forward Citations = 289(Granted Patents)


Company Filing History:


Years Active: 1994-2008

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21 patents (USPTO):Explore Patents

Title: Innovations in Biotechnology: The Patented Works of Michael J McCulloch

Introduction

Michael J McCulloch is a distinguished inventor based in Vacaville, California, renowned for his significant contributions to the field of biotechnology. With a portfolio that boasts 21 patents, McCulloch has focused on innovative solutions that advance both medical and agricultural sciences. His research primarily centers around the development of vaccines and protein synthesis using plant-based systems.

Latest Patents

One of McCulloch's latest patents is titled "Production of a parvovirus vaccine in plants as viral coat protein fusions." This invention involves the fusion of foreign peptide sequences to recombinant plant viral structural proteins—a method that has the potential to produce significant levels of fusion proteins economically. The technology utilizes biologically contained tobamoviruses to synthesize these fusion proteins in plants. Notably, the fusion proteins serve as valuable antigens that can induce the production of protective antibodies against parvoviruses, particularly in felines. In this groundbreaking work, he demonstrated that feline parvovirus epitopes could be fused to the N-terminus of the TMV coat protein, allowing for effective expression, extraction, purification, and the subsequent administration of these proteins to animals, resulting in protective immunity.

Career Highlights

Throughout his career, McCulloch has worked with several notable organizations that have propelled his research forward. He has been associated with companies like Large Scale Biology Corporation and Biosource Technologies, Inc., where he contributed to pioneering biotechnology research. His innovative techniques have paved the way for advancements in vaccine development and agricultural biotechnology.

Collaborations

Michael J McCulloch has collaborated with esteemed colleagues, including Stephen J Garger and R. Barry Holtz. These partnerships have fostered a rich environment for innovation, allowing for the exchange of ideas and the development of cutting-edge biotechnological advancements.

Conclusion

Michael J McCulloch exemplifies the spirit of innovation within the biotechnology industry. Through his extensive portfolio of patents and collaborative efforts, he continues to contribute significantly to advancements in vaccine development and protein engineering. His dedication to research and innovation highlights the importance of utilizing plant-based systems in addressing both veterinary and medical challenges, setting a precedent for future research in this vital field.

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