Michael J McCauley

Title: Innovations by Michael J McCauley in Antibody Engineering

Introduction

Michael J McCauley, located in Abington, PA, is a notable inventor who has contributed significantly to the field of biotechnology. With two patents to his name, his work focuses on advancing the methods of antibody engineering, specifically related to site-specific conjugation.

Latest Patents

Michael's latest patents include:

1. *Site-specific conjugation of glycosylated monoclonal antibodies with transglutaminase*: This patent describes engineered antibodies that facilitate site-specific conjugation by a transglutaminase. It elaborates on the methods of achieving this conjugation, the resultant site-specifically conjugated antibodies, and various pharmaceutical compositions and uses linked to these innovations.

2. *Methods for site-specific conjugation of proteins containing glycosylated Fc domains*: This patent outlines methods that enable the site-specific conjugation of glycan-intact antibodies using a transglutaminase. The innovation highlights the maintenance of low-ionic strength conditions, which allows for effective and rapid conjugation without necessitating antibody deglycosylation, along with related pharmaceutical compositions and applications.

Career Highlights

Michael is currently working at Janssen Biotech, Inc., a company known for its commitment to innovative healthcare solutions. His contributions to the field have not only advanced scientific knowledge but also offered practical applications in therapeutic development.

Collaborations

Throughout his career, he has collaborated with talented colleagues such as Vadim Dudkin and Kristen Wiley. These collaborations have likely enriched his research and fostered a productive environment for innovation in antibody engineering.

Conclusion

Michael J McCauley is a valuable contributor to the field of biotechnology through his innovative patents and collaborative efforts. His work on site-specific conjugation of antibodies has the potential to significantly impact pharmaceutical applications, making him an important figure in modern therapeutic research.