The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 10, 2024
Filed:
May. 19, 2021
Applicant:
Janssen Biotech, Inc., Horsham, PA (US);
Inventors:
Vadim Dudkin, Chalfont, PA (US);
Shalom Goldberg, Merion Station, PA (US);
Michael J. McCauley, Abington, PA (US);
Kristen Wiley, Trappe, PA (US);
Assignee:
Janssen Biotech, Inc., Horsham, PA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 1/107 (2006.01); A61K 47/54 (2017.01); A61K 47/62 (2017.01); A61K 47/68 (2017.01);
U.S. Cl.
CPC ...
C07K 1/1077 (2013.01); A61K 47/549 (2017.08); A61K 47/62 (2017.08); A61K 47/68 (2017.08); C07K 2317/41 (2013.01); C07K 2319/30 (2013.01); C07K 2319/91 (2013.01);
Abstract
Provided herein are methods for site-specific conjugation of glycan intact antibodies by a transglutaminase. According to particular embodiments, the reaction conditions are maintained or reduced to a low-ionic strength condition, which allows for efficient and fast conjugation without the need for antibody deglycosylation. Also described are pharmaceutical compositions and uses related to the conjugation method.