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Title: Michael I Sherman: Innovator in DNA Binding Research
Introduction
Michael I Sherman is a notable inventor based in Glen Ridge, NJ (US), recognized for his contributions to the field of molecular biology. He holds a total of four patents, showcasing his innovative approach to understanding DNA binding mechanisms.
Latest Patents
Among his latest patents is a significant discovery related to sequence-specific DNA binding by the p53 protein. This invention highlights that specific sequences in the human genome are the sites of strong binding for wild-type p53 protein, while mutant forms of the protein do not exhibit this binding. These sequences have diagnostic applications, allowing for the detection of cells where the amount of wild-type p53 is diminished. Furthermore, they can be utilized to screen for agents that may correct the loss of wild-type p53 to DNA in cancer cells.
Career Highlights
Michael I Sherman has had a distinguished career, working with prestigious institutions such as The Johns Hopkins University and Genzyme Corporation. His work has significantly advanced the understanding of p53 protein functions and their implications in cancer research.
Collaborations
Throughout his career, Sherman has collaborated with esteemed colleagues, including Bert Vogelstein and Kenneth W Kinzler. These partnerships have further enriched his research and contributed to the scientific community's understanding of genetic mechanisms.
Conclusion
Michael I Sherman stands out as an influential inventor in the realm of DNA research, with his patents paving the way for advancements in cancer diagnostics and treatment. His work continues to inspire future innovations in the field.