Matthew D Shoulders

Title: Innovator Spotlight: Matthew D. Shoulders

Introduction

Matthew D. Shoulders, based in Cambridge, MA, is an accomplished inventor with a remarkable portfolio of five patents. His innovative work primarily focuses on advancements in biological systems, particularly in the area of directed evolution and collagen mimetics. Shoulders' contributions have significantly enhanced our understanding and capabilities in these fields.

Latest Patents

Among Shoulders' most recent patents, two stand out for their innovative approaches. The first patent, titled "Methods and compositions for performing continuous directed evolution," describes techniques for executing continuous directed evolution within complex biological systems, including metazoan cells. This groundbreaking work involves using engineered DNA viruses to perpetuate the evolution of a specific gene, utilizing an error-prone adenoviral polymerase to generate infectious viruses that can infect new cells.

The second notable patent, "Collagen mimics," details novel collagen mimetics, featuring a tripeptide unit with the formula (Xaa-Yaa-Gly). In this innovation, a bulky, non-electron withdrawing proline derivative is introduced to either the Xaa or Yaa position within the native collagen helix. This substitution enhances the stability of the helix, attributed solely to steric effects when compared to previously known collagen-related triple helices. Methods for synthesizing these novel collagen mimics are also disclosed in the patent.

Career Highlights

Throughout his career, Shoulders has been associated with reputable organizations such as the Wisconsin Alumni Research Foundation and the Massachusetts Institute of Technology, where he has contributed to cutting-edge research and development in his areas of expertise. His work at these institutions reflects his commitment to innovation and advancement in the field of biology.

Collaborations

Matthew D. Shoulders has worked alongside renowned colleagues, including Ronald Thaddeus Raines and Jonathan Allen Hodges. These collaborations have fostered a dynamic research environment, allowing for the cross-pollination of ideas and techniques that enhance their collective contributions to scientific advancement.

Conclusion

In conclusion, Matthew D. Shoulders exemplifies the spirit of innovation through his pioneering work in directed evolution and collagen mimetics. With a strong portfolio of patents and a history of collaboration with esteemed peers, Shoulders continues to carve a significant path in the realm of biological research, demonstrating the profound impact of innovative thinking in addressing complex biological challenges.