The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 25, 2019
Filed:
Aug. 02, 2017
Applicant:
Wisconsin Alumni Research Foundation, Madison, WI (US);
Inventors:
Ronald T. Raines, Cambridge, MA (US);
Matthew D. Shoulders, Cambridge, MA (US);
Jonathan A. Hodges, Durham, NC (US);
Assignee:
Wisconsin Alumni Research Foundation, Madison, WI (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 14/78 (2006.01); C07K 5/097 (2006.01); C07K 14/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/78 (2013.01); C07K 5/0821 (2013.01); C07K 14/001 (2013.01);
Abstract
Novel collagen mimics are disclosed with a tripeptide unit having the formula (Xaa-Yaa-Gly),where one of the positions Xaa or Yaa is a bulky, non-electron withdrawing proline derivative. By substituting a proline derivative at either the Xaa or Yaa position in the native collagen helix, the stability of the helix is increased due solely to steric effects relative to prior known collagen-related triple helices. Methods are also disclosed for making the novel collagen mimics.