Masanobu Sugawara

Title: Masanobu Sugawara: Innovator in Pharmaceutical Chemistry

Introduction

Masanobu Sugawara, based in Chiba, Japan, is a distinguished inventor with a remarkable portfolio of six patents. His work primarily revolves around pharmaceutical chemistry, contributing significantly to the development of useful compounds for medical applications.

Latest Patents

One of Masanobu Sugawara's latest inventions is a process for producing optically active α-methylcysteine derivatives. This innovative method presents a straightforward industrial process for generating L- or D-optically active α-methylcysteine derivatives or their salts from readily available, low-cost raw materials. The process employs a racemic N-carbamoyl-α-methylcysteine derivative that is D-selectively cyclized with hydantoinase. This leads to the creation of D-5-methyl-5-thiomethylhydantoin derivatives alongside N-carbamoyl-α-methyl-L-cysteine derivatives, which undergo deprotection and hydrolysis to yield the desired products.

Another notable patent involves the method for producing (R)-3-[4-(trifluoromethyl)phenylamino]-pentanoic acid amide derivatives. This invention streamlines the production of an (R)-3-[4-(trifluoromethyl)phenylamino]-pentanoic acid amide derivative, crucial as an intermediate for pharmaceutical products, particularly as an inhibitor of cholesteryl ester transfer protein (CETP). By using (S)-N-[4-(trifluoromethyl)phenyl]-3-hydroxypentanoic acid amide sourced from easily accessible materials, the method successfully synthesizes the desired derivatives.

Career Highlights

Throughout his career, Masanobu Sugawara has collaborated with notable firms such as Kaneka Corporation and Pfizer Corporation. His innovative approaches have indeed played a vital role in pharmaceutical advancements.

Collaborations

In addition to working with prominent companies, he has teamed up with esteemed coworkers, including Kenji Inoue and Nobuo Nagashima. These collaborations have likely enhanced the breadth and impact of his work in the field of pharmaceutical chemistry.

Conclusion

Masanobu Sugawara's contributions to pharmaceutical chemistry are both significant and impactful. Through his innovative patents, he continues to serve as an inspiration to inventors and researchers alike, highlighting the importance of creativity and collaboration in the advancement of science and technology.