The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 29, 2007
Filed:
Mar. 16, 2004
Tatsuyoshi Tanaka, Takasago, JP;
Masanobu Sugawara, Takasago, JP;
Hirofumi Maeda, Takasago, JP;
Akira Nishiyama, Takasago, JP;
Yoshihiko Yasohara, Takasago, JP;
Nobuo Nagashima, Takasago, JP;
Tatsuyoshi Tanaka, Takasago, JP;
Masanobu Sugawara, Takasago, JP;
Hirofumi Maeda, Takasago, JP;
Akira Nishiyama, Takasago, JP;
Yoshihiko Yasohara, Takasago, JP;
Nobuo Nagashima, Takasago, JP;
Pfizer Inc., New York, NY (US);
Abstract
The present invention provides a method for easily producing an (R)-3-[4-(trifluoromethyl)phenylamino]-pentanoic acid amide derivative useful for an intermediate for pharmaceutical products, particularly an inhibitor of a cholesteryl ester transfer protein (CETP) from easily available raw materials. In the present invention, (S)-N-[4-(trifluoromethyl)phenyl]-3-hydroxypentanoic acid amide prepared from easily available raw materials leads a production of (R)-4-ethyl-1-[4-(trifluoromethyl)phenyl]-2-azetidinone to give (R)-3-[4-(trifluoromethyl)phenylamino]-pentanoic acid amide. Furthermore, (R)-4-ethyl-1-[4-(trifluoromethyl)phenyl]-2-azetidinone is reacted with a carbamic acid ester to give an (R)-3-[4-(trifluoromethyl)phenylamino]-pentanoic acid amide derivative.