Location History:
- Broomsfield, CO (US) (1997)
- Broomfield, CO (US) (1990 - 2020)
Company Filing History:
9 out of 45 
3 out of 24 
3 out of 8 Years Active: 1990-2020
Title: Innovations and Contributions of Mary S. Rosendahl
Introduction
Mary S. Rosendahl is a prominent inventor based in Broomfield, Colorado. She has made significant contributions to the field of biotechnology, holding a total of 18 patents. Her work primarily focuses on enhancing the properties of proteins and peptides, which has important implications in various medical and industrial applications.
Latest Patents
One of her latest patents involves the use of hydrophobic organic acids to increase the hydrophobicity of proteins and protein conjugates. This method includes creating a protein-PEG conjugate salt with enhanced hydrophobicity. The process begins with an aqueous protein solution that contains a protein and a pH buffer. Subsequently, a polyethylene glycol is reacted with the protein to form a protein-PEG conjugate. The method further includes protonating an amino group on the protein-PEG conjugate with a hydrophobic organic acid in an organic phase, resulting in a protein-PEG conjugate salt that possesses a hydrophobic anion, thereby increasing its hydrophobicity.
Another notable patent pertains to cysteine analogs of exendin-4. This patent discloses a method for refolding a protein or peptide that lacks essential disulfides but contains at least one free cysteine residue. Additionally, it describes polymer interferon-gamma conjugates created through the chemical coupling of polymers, such as polyethylene glycol moieties, to interferon-gamma, particularly via a free cysteine in the protein. The patent also includes analogs of bioactive peptides that can be utilized to develop longer-acting versions of various peptides, including glucagon and glucagon-like peptides.
Career Highlights
Mary has worked with several companies throughout her career, including Bolder Biotechnology, Inc. and Somatogen, Inc. Her innovative approaches and research have significantly advanced the understanding and application of protein chemistry.
Collaborations
Mary has collaborated with notable professionals in her field, including George N. Cox and Daniel H. Doherty. These collaborations have further enriched her research and contributed to her success as an inventor.
Conclusion
Mary S. Rosendahl's contributions to biotechnology through her patents and collaborations highlight her role as a leading inventor in the field. Her innovative methods for enhancing protein properties continue to have a lasting impact on various applications.