The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 11, 2007
Filed:
May. 16, 2001
Applicants:
Mary S. Rosendahl, Broomfield, CO (US);
George N. Cox, Louisville, CO (US);
Daniel H. Doherty, Boulder, CO (US);
Inventors:
Mary S. Rosendahl, Broomfield, CO (US);
George N. Cox, Louisville, CO (US);
Daniel H. Doherty, Boulder, CO (US);
Assignee:
Bolder Biotechnology, Inc., Boulder, CO (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12P 21/00 (2006.01); C07K 5/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
The present invention relates to novel methods for making and refolding insoluble or aggregated proteins having free cysteines in which a host cell expressing the protein is exposed to a cysteine blocking agent. The soluble, refolded proteins produced by the novel methods can then be modified to increase their effectiveness. Such modifications include attaching a PEG moiety to form PEGylated proteins.