Company Filing History:
4 out of 531 
3 out of 4 Years Active: 2009-2016
Title: Inventor Martine Petronella Bos: Pioneer in Immunogenic Compositions
Introduction
Martine Petronella Bos, an accomplished inventor based in Utrecht, Netherlands, has made significant contributions to the field of immunology. With a remarkable portfolio of four patents, his work focuses on innovative compositions that enhance bacterial immunity.
Latest Patents
Among Martine's latest inventions is a groundbreaking immunogenic composition that incorporates neisserial blebs with upregulated levels of the NMB0964 antigens. This invention aims to generate bacterial antibodies against the antigen, enhancing the effectiveness of immunological responses. The methods outlined in the patent also describe how to upregulate expression by removing the zinc repression mechanism within the cell or promoter, or through the removal of zinc from the culture medium.
Another important patent discloses a Gram-negative bacterium, specifically engineered to down-regulate the expression of a protein involved in LPS transport to the outer membrane. This innovation results in a decreased level of LPS in the outer membrane compared to a wild-type Gram-negative bacterium. The down-regulation of Imp and MsbA proteins leads to the development of outer membrane vesicle preparations that can be used in vaccines, providing protection against bacterial infections.
Career Highlights
Martine has built a distinguished career, working with notable organizations such as GlaxoSmithKline Biologicals SA and the University of Utrecht. His experiences at these institutions have enabled him to collaborate on advanced research projects and further his innovative endeavors in the field of biotechnology.
Collaborations
Throughout his career, Martine has collaborated with esteemed colleagues in his field, notably Jan Poolman and Johannes Petrus Maria Tommassen. Their collective expertise has contributed to the development of cutting-edge solutions in immunology and vaccine research.
Conclusion
Martine Petronella Bos stands out as a visionary inventor whose work in immunogenic compositions has the potential to make a significant impact on healthcare. With his innovative patents and collaborations within the scientific community, Martine continues to push the boundaries of research, contributing to the fight against bacterial infections. His journey exemplifies the vital intersection of invention and public health.