The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 16, 2016
Filed:
Mar. 06, 2009
Martine Petronella Bos, Utrecht, NL;
Jan Poolman, Rixensart, BE;
Michiel Stork, Utrecht, NL;
Johannes Petrus Maria Tommassen, Utrecht, NL;
Vincent Weynants, Rixensart, BE;
Martine Petronella Bos, Utrecht, NL;
Jan Poolman, Rixensart, BE;
Michiel Stork, Utrecht, NL;
Johannes Petrus Maria Tommassen, Utrecht, NL;
Vincent Weynants, Rixensart, BE;
GlaxoSmithKline Biologicals, S.A., Rixensart, BE;
Abstract
The present invention relates to immunogenic compositions comprising neisserial blebs with upregulated levels of the NMB0964 antigens such that bacterial antibodies are generated against said antigen. Methods are also provided to upregulate expression through removal of the zinc repression mechanism of the cell or promoter or through removal of zinc from the culture medium.