The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 08, 2009
Filed:
Dec. 21, 2004
Martine Petronella Bos, Utrecht, NL;
Jan Poolman, Rixensart, BE;
Boris Tefsen, Utrecht, NL;
Johannes Petrus Maria Tommassen, Utrecht, NL;
Martine Petronella Bos, Utrecht, NL;
Jan Poolman, Rixensart, BE;
Boris Tefsen, Utrecht, NL;
Johannes Petrus Maria Tommassen, Utrecht, NL;
GlaxoSmithKline Biologicals S.A., Rixensart, BE;
University of Utrecht, Utrecht, NL;
Abstract
The present invention discloses a Gram negative bacterium in which the expression of a protein involved in LPS transport to the outer membrane is functionally downregulated such that the level of LPS in the outer membrane is decreased compared to a wild-type Gram negative bacterium. Down regulation of Imp and MsbA proteins can result in such a bacterium. Outer membrane vesicle preparations derived from the Gram negative bacterium of the invention can be used in vaccines to provide protection against bacterial infection.