Martin D Sigg, Jr

Title: Martin D. Sigg, Jr.: RNA Expression Constructs and Gene Silencing

Introduction

Martin D. Sigg, Jr. is an inventor associated with Philadelphia, Pennsylvania, and Alnylam Pharmaceuticals, Inc. His patent work concerns RNA expression constructs designed to support gene silencing.

Latest Patents

Sigg is associated with 1 patent, titled “Multiple RNA Polymerase III Promoter Expression Constructs.” The patent describes constructs containing at least two different RNA polymerase III promoters, each linked to a sequence encoding an RNA effector molecule. It also covers constructs with multiple promoters linked to sequences encoding short hairpin RNA molecules, including molecules with single or multiple fingers. These constructs are intended for in vivo delivery of RNA molecules that can silence genes, including viral genes associated with hepatitis B and hepatitis C.

Career Highlights

At Alnylam Pharmaceuticals, Inc., Sigg’s patent work reflects an emphasis on RNA-based approaches to gene silencing. The disclosed constructs combine multiple promoters and RNA effector sequences to support the delivery of gene-silencing molecules.

Collaborations

Catherine Julia Pachuk and Daniel E. McCallus are identified as Sigg’s coworkers. Their shared association with Alnylam Pharmaceuticals provides professional context for his work in RNA-based technologies.

Conclusion

Martin D. Sigg, Jr.’s patent on multiple RNA polymerase III promoter expression constructs describes a strategy for delivering RNA molecules that may silence viral and other genes.