Alnylam Pharmaceuticals, Inc.

Martin D Sigg, Jr

Catherine Julia Pachuk

Chandrasekhar Satishchandran

Daniel E McCallus

Expression constructs comprising at least two different RNA polymerase III promoters, wherein each promoter is operably linked to a nucleic acid sequence encoding an RNA effector molecule, are disclosed herein. Further provided are expression constructs comprising multiple polymerase III promoters operably linked to sequences encoding short hairpin RNA molecules, which may comprise single and/or multiple fingers. The provided constructs are useful for in vivo delivery of RNA molecules effective in gene silencing, including of viral genes including HBV and HCV.

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Philadelphia, PA, United States of America

Martin D Sigg, Jr