The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 26, 2011
Filed:
Aug. 23, 2005
Catherine J. Pachuk, Blue Bill, PA (US);
Daniel E. Mccallus, Oaks, PA (US);
Chandrasekhar Satishchandran, Lansdale, PA (US);
Martin D. Sigg, Jr., Philadelphia, PA (US);
Catherine J. Pachuk, Blue Bill, PA (US);
Daniel E. McCallus, Oaks, PA (US);
Chandrasekhar Satishchandran, Lansdale, PA (US);
Martin D. Sigg, Jr., Philadelphia, PA (US);
Alnylam Pharmaceuticals, Inc., Cambridge, MA (US);
Abstract
Expression constructs comprising at least two different RNA polymerase III promoters, wherein each promoter is operably linked to a nucleic acid sequence encoding an RNA effector molecule, are disclosed herein. Further provided are expression constructs comprising multiple polymerase III promoters operably linked to sequences encoding short hairpin RNA molecules, which may comprise single and/or multiple fingers. The provided constructs are useful for in vivo delivery of RNA molecules effective in gene silencing, including of viral genes including HBV and HCV.